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A significant reduction in urine output can occur with certain forms of kidney injury.
This is more concerning when it appears suddenly and is accompanied by swelling, nausea, weakness, or severe illness.
## 9. Very Dark Urine
Dark urine can occur because of dehydration, foods, medications, blood, or other medical problems.
Persistent or unexplained dark urine should be evaluated, especially if it occurs with jaundice, pain, or changes in urination.
## 10. Persistent Itching
Advanced kidney disease can affect mineral balance and allow certain substances to accumulate in the body.
This may contribute to persistent itching.
But itching is extremely common and can also result from dry skin, allergies, liver disease, medications, or skin conditions.
## 11. Very Dry Skin
Dry, rough, or flaky skin can sometimes accompany kidney disease, particularly when mineral and fluid balance are affected.
Still, dry skin alone is much more likely to have another cause.
## 12. Muscle Cramps
