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* significantly reduced urine output
* swelling in the legs or ankles
* blood in the urine
* persistent nausea
* severe weakness
* unexplained shortness of breath
* confusion
* severe flank or back pain
Kidney disease may also cause no obvious symptoms in its early stages, which is why blood and urine testing can be important.
## “Natural” Does Not Mean Harmless
This is one of the most important lessons when using supplements.
Plants contain biologically active chemicals. Concentrating those chemicals into extracts, powders, or capsules can create effects that are very different from consuming small amounts of the plant as food.
The NIH Office of Dietary Supplements specifically cautions that natural products can still cause harm and recommends discussing supplement use with healthcare professionals.
## How to Use Supplements More Safely
A few precautions can reduce unnecessary risk:
* Avoid megadoses unless specifically recommended medically.
* Check whether several supplements contain the same nutrient.
* Tell your doctor and pharmacist about all supplements you take.
* Be especially careful with products marketed for rapid weight loss, bodybuilding, or detoxification.
* Choose products from reputable manufacturers.
