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* Avoid using supplements as substitutes for prescribed treatment.
* If you have liver or kidney disease, discuss supplements before starting them.
* Stop using a supplement and seek medical advice if you develop concerning symptoms.

## The Bottom Line

Most vitamins and supplements are not inherently dangerous when used appropriately.

Problems are more likely when people take **very large doses, use multiple overlapping products, take concentrated herbal extracts, or continue supplements despite underlying liver or kidney disease**.

Vitamin A, vitamin D, vitamin C, high-dose niacin, iron, concentrated green tea extract, kava, multi-ingredient herbal formulas, and creatine in people with kidney problems all deserve particular attention.

Supplements can be useful when there is a genuine need, but more is not always better. When in doubt—especially if you take prescription medications or already have liver or kidney problems—review your supplement list with a healthcare professional before increasing the dose or ad