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* nutrient accumulation
* medication interactions
* electrolyte abnormalities
* worsening kidney function
* liver injury
People with chronic kidney disease are also sometimes advised to limit or avoid certain minerals depending on their blood results and stage of disease.
Supplement choices in this situation should be individualized rather than based on internet recommendations.
## Watch for Possible Signs of Liver Injury
Seek medical advice promptly if you develop symptoms such as:
* yellowing of the skin or eyes
* unusually dark urine
* persistent nausea or vomiting
* unusual fatigue
* significant itching
* loss of appetite
* pain in the upper right abdomen
* pale stools
These symptoms do not automatically mean that a supplement caused liver damage, but they deserve medical evaluation.
## Watch for Possible Signs of Kidney Problems
Symptoms that may require medical attention include:
